Exploring the DNA Repair Mechanism free essay sample

A summary, review and critique of cutting edge research into the mechanisms behind DNA repair in eukaryotes. The importance of DNA repair mechanisms and the fascinating enzymes involved within them have been underestimated. Without these repair proteins, our DNA would be fatally mutated at such a frequency to extinguish life as we know it. This paper reviews a piece of current research on the proteins that allow repair to occur. Some novel details about the flexibility and dynamics of several proteins are revealed through 3-D imaging of the proteins. The regulation of these proteins is also postulated in light of the data collected. Replication protein A (RPA) is a nuclear single stranded DNA (ssDNA) binding protein in eukaryotes and is essential to DNA replication, recombination and repair. With all the cell division going on in a developing embryo, the chance of deleterious mutation goes up for certain and thus there is a greater need for a functioning DNA repair mechanism. We will write a custom essay sample on Exploring the DNA Repair Mechanism or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page There is definitely a lot of replication and transcription of DNA going on during early post-fertilization growth and mitotic divisions that need to be conserved. Also important is the all-important preservation of gametogenesis during the first week of development. Without means to repair all the statistically inevitable mistakes during mitosis and meiosis, none of us would have the functional gametes to pass on viable DNA to future generations. The repair protein mechanisms and the role RPA plays to lower the activation energy of the reactions makes sense to be selected for in order for our selfish genes to continue to thrive. RPA was known prior to this study and so was something about its role in excision repair, but what was not known was the specific tertiary and quaternary structure of the subunits and active sites in the enzyme that allowed for the observed activity.

Proposal for The Corporate Governece

Proposal for The Corporate Governece MSc Dissertation Proposal on:Gender diversity and board-level governance impact on the agency cost and firm performanceStatement of proposed aims, points of interests and importance of outcomes.On the increment of a firm to a threshold, a common phenomenon is observed that for many years professional bodies have been seeking for an effective way of measure for the following factors: Firm Governance, Effectiveness of Agency Costs, Firm Performance and value in order to maintain the organisation is a logical order. However, from the reviewed related articles and self knowledge that there are many proposed ways of measure of above stated factors and most importantly, they seem to act on an individual basis with attached conditions in certain extent. Therefore, by consulting with the official released literatures the brief of proposed aims of this dissertation is set as follows to discuss and merge the findings from existing professional bodies to form a compact and comprehensive method( s) in reference to firm's Governance, Agency Cost, Performance and Firm Value:Initially, the measure of NED independent level is discussed and to conclude if better or higher independent level is preferred within this context. How the independent level of the NED can reduce the Agency Cost(s) and to increase the Firm Value.Within range of independence level, two further discussions are attached in terms of Women and Social Network. The analysis is carried out by comparing women's social network with men's to investigate whether women are more independent than men.Attendance behaviours of individual directors and the committee assignment are measured to verify if the independent of a director is associated with good governance such that high attendance is strongly associated with my " independent " measure or to form the relationship in between.Cash flow and divided payment are also used at a...

Business Synoptic 1f Essay Example | Topics and Well Written Essays - 4000 words

Business Synoptic 1f - Essay Example Other major brands include Arrowhead and Perrier, baby foods like Gerber, cereals like Cheerios, ice cream including the famed Haagen-Daaz, microwavable food like Hot Pocket and Stouffers, health lines like PowerBar and Jenny Craig products, pet food like Dog Chow and Friskies, and professional food products (Nestle, 2010). With a few exceptions like Perrier and Haagen-Daaz, Nestle tends to target the lowest common denominator of the market, and most of their products are worldwide household names. They sell a tremendous variety of products, but all of their products have something to do with nutrition or food. They do sometimes attempt to control all sectors of the market. For example, they sell both the low-end Drumstick ice cream bar and the higher end Haagen-Daaz; similarly, Stouffers and Hot Pockets sell to radically different demographics. Nestle realized that their growth rate, while constant over the 20th century and producing many beloved brands, was unsustainable in the lon g term. â€Å"Nestle realized by the early 1990s that it faced significant challenges in maintaining its growth rate. The large Western European and North American markets were mature. In several countries, population growth had stagnated and in some there had been a small decline in food consumption. The retail environment in many Western nations had become increasingly challenging, and the balance of power was shifting away from the large-scale manufacturers of branded foods and beverages and toward nationwide supermarket and discount chains†. Many companies would experiment with different branding options, opening up new markets, new marketing schemes, etc. but would try to keep the core structure of the company intact. Nestle did these things: Its brand portfolio, as we've seen above, goes from luxury to bargain, is targeted at numerous demographics and income levels, and is increasingly expanding to try to get into different markets. Yet that is not all they did, and the ir choice of a new structure helps explain their success. Nestle's strategy for entering new markets and avoiding the inundation of existing ones is simple: â€Å"In general, the company's strategy has been to enter emerging markets early-before competitors and build a substantial position by selling basic food items that appeal to the local population base, such as infant formula, condensed milk, noodles, and tofu. By narrowing its initial market focus to just a handful of strategic brands, Nestle claims it can simplify life, reduce risk, and concentrate its marketing resources and managerial effort on a limited number of key niches. The goal is to build a commanding market position in each of these niches. By pursuing such a strategy, Nestle has taken as much as 85 percent of the market for instant coffee in Mexico, 66 percent of the market for powdered milk in the Philippines, and 70 percent' of the markets for soups in Chile. As income levels rise, the company progressively mov es out from these niches, introducing more upscale items such as mineral water, chocolate, cookies and prepared foodstuffs†. This is a disruptive strategy (Malstrom, 2008a; Malstrom, 2008b). Disruptive strategies involve creating a new market: â€Å"